![]() The etiology of lattice degeneration is unknown, though theories include developmental anomalies of the internal limiting membrane, embryologic vascular anastomosis, localized retinal ischemia, or the contention that it is a primary vitreopathy leading to the formation of abnormal vitreous traction. Wagner Syndrome may also present with lattice degeneration. This feature is not believed to be congenital, but rather, develops during childhood and progresses throughout life. Hereditary Vitreopathies: Stickler Syndromemay present with unique radial perivascular lattice-like degeneration.Nonetheless, lattice degeneration is frequently cited as a risk factor for development of RRD given its strong association with this entity. In one study, three out of 423 eyes (0.7%) with lattice degeneration developed clinical retinal detachments and sixteen (3.7%) developed subclinical retinal detachments. However, and importantly, the reverse is quite different: few eyes with lattice degeneration actually develop retinal detachments. ![]() Retinal Detachment: Approximately 20 to 30% of patients with a rhegmatogenous retinal detachment (RRD) have lattice degeneration. ![]()
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